As long as the indications, dosage and the number of doses are strictly controlled, closed treatment is generally not harmful. But the physical state is not good, suffering from serious cardiovascular disease patients better not to use, prone to vascular accidents. Doctors if the closed treatment during the injection location or improper operation methods, there may also be damage. In addition, the closure treatment is relatively safe. Closed treatment is mainly for acute and chronic injuries and degeneration of muscles, ligaments, fascia, tendon sheaths, synovial membranes and other soft tissues, as well as degenerative lesions of bone and joint, have a relatively significant effect. In the case of tuberculosis, septic disease and tumor disease of the bone and joint, it is absolutely forbidden to apply closure therapy. If the disease requires the use of hormonal drugs, once the dose is too large, the use of too long, may lead to osteoporosis, femoral head necrosis, tendon ligament degeneration or even rupture, resulting in more serious consequences.