Ibuprofen may cause adverse reactions in the gastrointestinal tract during taking the drug, such as nausea, vomiting, stomach pain, indigestion, abdominal pain, diarrhea, etc. If you take ibuprofen on an empty stomach, these symptoms may be aggravated, and serious adverse reactions such as gastric ulcer, duodenal ulcer and gastrointestinal bleeding may occur. Therefore, ibuprofen should not be taken on an empty stomach, but 15-30 minutes after a meal. Ibuprofen is available in various forms, such as ibuprofen tablets, ibuprofen extended-release capsules and ibuprofen suspension. It should be noted that when using ibuprofen extended-release capsules, the capsules should not be opened and chewed, but must be taken whole with warm water.