Herpes zoster neuralgia can occur throughout the course of the disease (before, during, and after), and the pain that persists in some people 1 month after the rash has healed is called herpes zoster-sequelae neuralgia, and its treatment varies. 1. Herpes zoster neuralgia before the rash heals: (1) If pain occurs, calcium channel modulators (pregabalin and gabapentin, both specific for herpes zoster) need to be added early. (2) On top of this, opioids or tramadol extended-release tablets, etc., may be used. (3) Tricyclic antidepressants, such as amitriptyline, can be used as appropriate. For patients who are not well treated with medication, minimally invasive neurointerventional analgesic treatment and spinal cord electrical stimulation can often have a good therapeutic effect, and the earlier the timing of the intervention, the better the effect is generally. 2, the pathogenesis of postherpetic neuralgia to has not been fully clarified, epidemiology shows that poor general condition, more underlying diseases, advanced age, late treatment, special sites of herpes zoster are more likely to leave postherpetic neuralgia. Early detection, early initiation of antiviral therapy, nerve nutrition and analgesic treatment in the recommended amounts are key to the prevention and treatment of herpes zoster neuralgia.