Nowadays, there are more hepatitis B mothers, and we are all very anxious about the problem of breastfeeding. For this issue, although there is still controversy in medicine, but in view of the role of breast milk to the baby, other foods can not be replaced, so generally recommended: 1, in many “big three positive” mother’s survey found that breastfeeding and artificial feeding on the infant hepatitis B virus infection rate is not significantly different. There is no significant difference in the antibody production rate of newborns vaccinated with hepatitis B vaccine when breastfeeding or artificial feeding is reported by domestic mothers with “major triple-positive”. It can be said that so far there is no proof that hepatitis B virus can be transmitted through breast milk. 2. For newborns of HBsAg-positive mothers, 10 μg of yeast hepatitis B vaccine should be given as early as possible within 24 h after birth, together with hepatitis B immunoglobulin (HBIG) injections at different sites (preferably within 12 h after birth, at a dose of ≥100 IU), which can significantly improve the effect of blocking mother-to-child transmission. It is also possible to administer 1 dose of HBIG within 12 h of birth, followed by a second dose of HBIG 1 month later, along with 10 μg of hepatitis B vaccine, and 10 μg of hepatitis B vaccine 1 and 6 months later, respectively. The latter is less convenient than the former, but its protection rate is higher than the former. Therefore, newborns can be breastfed by HBsAg-positive mothers after receiving hepatitis B vaccine and HBIG within 12 hours of birth.