Whether or not a creatinine of 150 μmol/L or more is dangerous is based primarily on the cause of the elevated creatinine and the complications. Elevated creatinine includes both physiological and pathological causes and cannot be generalized. Under normal circumstances, the blood creatinine index is 53-106 μmol/L in men and 44-97 μmol/L in women. Physiological causes such as excessive meat consumption and elevated creatinine can occur after strenuous exercise, and usually return to normal after elimination of the triggering factors, which is usually not dangerous. Pathological causes such as acute and chronic glomerulonephritis, pyelonephritis, etc. creatinine reaches 150 μmol/L or above indicates that the kidney function is damaged and the renal parenchyma is destroyed, which is usually more dangerous and needs to be treated actively. It is suggested that patients with creatinine elevation up to 150μmol/L need to consult a doctor in time and receive targeted treatment under the doctor’s guidance, so as to avoid delaying the condition and aggravating the destruction of renal function.