Positive CENPB antibodies mean positive anti-adherence protein B antibodies and often indicate rheumatic diseases. CENPB antibody is an autoantibody that was first found to be positive in the sera of patients with scleroderma, and subsequent research and clinical work has revealed that CENPB antibody positivity can also be found in autoimmune diseases such as systemic lupus erythematosus, Raynaud’s disease, rheumatoid arthritis, connective tissue disorders, Scheugelen’s syndrome, polymyositis/dermatomyositis, and other autoimmune diseases. CENPB positivity is of great significance in the diagnosis and evaluation of the efficacy of autoimmune diseases. It should be noted that when CENPB positivity occurs, it is recommended that the patient go to a regular hospital in a timely manner, to clarify the cause of the disease, and to carry out treatment under the guidance of the doctor.