Overview: Atherosclerotic occlusive disease is a chronic arterial occlusive disease caused by atherosclerotic lesions in the arteries, mainly affecting large and medium-sized arteries such as the lower abdominal aorta, iliac arteries, and femoral arteries. Due to atherosclerotic plaque, arterial middle layer degeneration and secondary thrombosis, the lumen is gradually occluded and the lower limbs become ischemic. The main clinical manifestations are coldness, numbness, pain, intermittent claudication of the affected limb, loss of arterial pulsation, nutritional impairment of the limb tissues, and ulceration or gangrene of the toes or feet. Diagnosis: Generally, the patient has symptoms of chronic ischemia of the lower limbs, the age of onset is above 45 years, the lesion mainly involves large and medium-sized arteries, such as the lower abdominal aorta, iliac artery, femoral artery, etc. The arterial pulsation in these corresponding parts is weakened or disappears, and X-ray plain film may show arteries with patchy calcification, and the ankle/brachial index may be less than 1 on examination of non-injured vessels, or up to 0.5 or less in severe cases. Based on the above symptoms and examination, the diagnosis can be made. Arteriography may show multiple elongated and twisted arteries with diffuse irregular lumen narrowing or segmental occlusion. Symptoms: The earliest symptoms of this disease are coldness, numbness, and intermittent claudication in the affected limbs. If occlusion occurs in the lower abdominal aorta or iliac artery, there is soreness, weakness, and pain throughout the buttocks and lower extremities after walking, and if symptoms occur in the lower legs, this suggests a possible femoral artery occlusion. As the disease progresses, the ischemia of the affected limb worsens, and persistent resting pain may occur in the toes, foot or lower leg in a quiet state, more intense at night, and the patient often sits with his feet in his arms and stays awake all night. The affected toes, feet or calves have pale complexion, decreased temperature, decreased sensation, thinning skin, muscle atrophy, thickened and deformed toenails, and sparse bone. Under severe ischemia produces ulcers and gangrene in the toes, feet or lower legs.