Lower extremity pain is a common disease in the human body, especially prevalent in the middle-aged and elderly, and has a great impact on people’s daily life. There are many causes of lower extremity pain, such as: lumbar strain loss, lumbar disc disease, sciatic nerve disease, patellar tenderness and so on. Although these diseases can cause a lot of pain to people, they usually do not cause adverse consequences . However, there is one disease that causes pain in the lower limbs that must be taken seriously, because if these diseases are not treated early, they can eventually lead to limb necrosis, limb loss, or even death, and this is the disease known as the limb killer – peripheral atherosclerotic occlusive disease. The prevalence of peripheral atherosclerotic occlusive disease in men over 65 years of age is 10%, and only 20% of patients with peripheral arterial disease are diagnosed with this disease. As the disease progresses, atherosclerotic plaques are formed in the arterial lining of the affected arteries and gradually increase, which is like a sewer pipe buried underground for many years, with rusty lumen and covered with dirt. 2. The further development of atherosclerotic plaque leads to the complete occlusion of the arterial lumen. This is the main reason why the arterial supply to the lower extremities is inadequate. The performance of peripheral atherosclerotic occlusive disease causing limb disease is divided into four stages according to the degree of the disease: Stage 1: the affected limb appears cold, numb feeling, Stage 2: the affected limb discomfort, soreness, pain, and even must stop to rest for a few minutes after the normal walking distance before continuing to walk, this phenomenon is called “intermittent claudication” in medicine. This phenomenon is medically called “intermittent claudication”. The shorter the distance the symptoms appear when walking, the more severe the condition. Stage 3: The patient still has pain in the affected limb when not exercising and resting in bed. At this time, the blood supply to the arteries of the limb is already very little and cannot meet the basic physiological needs of the body, which is called “resting pain” in medical science. The fourth stage: it is called “necrosis stage”. Generally, the affected limb starts to dry out, discolor and atrophy from the toe end, which gradually expands and eventually forces the limb to be amputated and disabled. Risk factors for peripheral atherosclerotic occlusive disease: Risk factor 1: Age Risk factor 2: Smoking Risk factor 3: Hypertension Risk factor 4: Diabetes Risk factor 5: Hyperlipidemia Risk factor 6: Hypercoagulability Comprehensive treatment Control of risk factors: For patients with peripheral atherosclerotic occlusive disease, it is necessary to have a comprehensive understanding of the patient’s risk factors and to provide appropriate interventions. For example, smoking cessation, blood glucose control, hypertension control, lipid control, etc. Current medicine is capable of treating such diseases well, thus avoiding adverse consequences. Depending on the condition, treatment can be pharmacological, balloon dilation and stenting, surgery for vascular bridging, etc. The key is that the patient must be seen in time before the onset of the “necrotic phase”, which is generally best treated at the end of the second and beginning of the third stage.