The so-called “Eugenics IV test”, also known as the “Infection IV test”, is designed to check whether the mother of a woman preparing for pregnancy is infected with Toxoplasma gondii, rubella, cytomegalovirus and herpes simplex virus. The test is based on the presence of antibodies to these pathogens – IgM and IgG – in the maternal serum: IgM, acute antibodies, indicates a recent infection; IgG, chronic antibodies, indicates a previous infection. Toxoplasma gondii infection in pregnant women may cause hydrocephalus, microcephaly, and central nervous system dysplasia in the fetus; rubella virus infection may cause congenital cataract, eye defect, ear defect, deafness, microcephaly, and heart malformation in the fetus, i.e. “congenital rubella syndrome”; cytomegalovirus The active infection of cytomegalovirus may cause fetal brain, central nervous system, retina and other dysplasia; herpes simplex virus infection may induce miscarriage, premature birth, malformation and so on. The so-called “five tests for eugenics” are the above-mentioned “four tests for infections” plus some other tests for reproductive tract infections, mainly the syphilis spirochete antibody test which has a greater impact on fertility and fetus. Syphilis spirochetes can infect the fetus, resulting in sepsis and death of the newborn, and those who survive may also be congenital syphilis patients, even if they are asymptomatic in childhood, they may show up as syphilis stage III in adolescence. The initials of the five eugenic tests in English are arranged to form the English word TORCH (torch, torch), so it is also called “TORCH test”. In general, the above five pathogens can infect the fetus through the placenta and birth canal, causing intrauterine infection, miscarriage, intrauterine growth retardation, stillbirth, congenital malformation, neonatal infection, and even adolescent developmental disorders. The clinical manifestations are complex and varied, ranging from invisible to overt infections, from fetal death to serious malformations and sequelae, and are a serious risk to the mother, fetus and newborn, which should be prevented by active measures. Therefore, the eugenics five tests are best carried out before pregnancy, and then rechecked in early pregnancy if necessary. The source of Toxoplasma gondii infection is animals, and the way of infection is close contact with animals and raw meat consumption. Women who are planning to get pregnant should stay away from pets and animals and not consume raw meat and milk products six months before pregnancy to avoid Toxoplasma infection. Women with a history of animal contact or raw food habits can be tested for Toxoplasma gondii antibodies before pregnancy, and for those who are IgM positive, it is recommended to wait 3 months before pregnancy. Rubella virus is an acute respiratory infection characterized by fever, rash and swollen lymph nodes behind the ear. Women who are planning to get pregnant should be tested for rubella virus antibodies six months before conception. If IgG antibodies are positive, this indicates a previous rubella virus infection and immunity, so there is no need for rubella virus-related antibody testing or rubella virus vaccination, and if rubella virus IgG antibodies are negative, rubella virus vaccination can be given three months before conception. Rubella vaccination is 98% effective and is a lifelong immunity. If the rubella vaccine is administered before pregnancy, first, you should use careful contraception and be sure not to conceive for 3 months; second, it is not necessary to retest for rubella virus-related antibodies in early pregnancy. If you have not been tested for rubella virus antibodies before pregnancy, and you are found to have rubella virus infection in early pregnancy, you should terminate the pregnancy and get pregnant again after 6 months. 3. Cytomegalovirus For cytomegalovirus infection, there is no safe and effective treatment drug and no vaccine. Primary infection in early pregnancy can cause much more damage to the fetus than secondary infection, and the main preventive measure is timely and accurate detection of primary infection in early pregnancy. Women who are planning to get pregnant can be tested for cytomegalovirus IgG antibodies before pregnancy, and those who are positive can stop doing the relevant tests, and primary infection will not usually occur after pregnancy, but secondary infection with flu-like symptoms after pregnancy cannot be ruled out. Those who are negative can be tested for cytomegalovirus IgG antibody affinity index and IgM antibody in early pregnancy. 4. Herpes simplex virus There are two types of herpes simplex virus, type I and type II. type I mainly causes infections of the skin and mucous membranes and organs above the waist and outside the genitals, while type II mainly causes infections below the waist and in the genital area. Most adults in China have had herpes simplex virus type I infections, and most women have acquired specific antibodies against herpes simplex virus, so intrauterine infections caused by this type of virus rarely occur. According to the literature, only a dozen cases of intrauterine infection with herpes simplex virus occurred worldwide in the 20 years from 1983 to 2003. Therefore, basically, this test can be disregarded before and during pregnancy. If there are signs of herpes simplex virus infection in the genital tract during pregnancy and confirmed by laboratory tests, a cesarean section is recommended during delivery. Syphilis spirochete Syphilis spirochete infection is one of the traditional classical sexually transmitted diseases, but also a global sexually transmitted disease. In the past two or three decades, the incidence rate in China has been on the rise. Syphilis spirochete antibody test before pregnancy, positive people need to further confirm the diagnosis, timely treatment. Cure before pregnancy. If infected early in pregnancy, you should receive regular treatment before 16 weeks of pregnancy.