There is no such thing as what cream is best for anal itching, anal itching may be caused by anal pruritus, hemorrhoids, perianal eczema and other diseases, patients can choose the appropriate treatment drugs according to the different causes, including pimecrolimus cream, hydrocortisone cream, compound dexamethasone cream, etc., the drug should be used in accordance with the doctor’s instructions. 1. Anal pruritus: For anal itching caused by anal pruritus, patients can use pimecrolimus cream, tacrolimus cream and other calcineurin inhibitors as prescribed by the doctor, and can also take oral doxepin hydrochloride tablets, chlorpheniramine maleate tablets and other antihistamines. In addition, patients can also take oral gabapentin capsules, pregabalin capsules and other anti-epileptic as well as anti-anxiety drugs. 2. Hemorrhoids: hemorrhoids can also lead to symptoms of anal itching, patients can follow the doctor’s instructions to use hydrocortisone cream, Dinaid cream and other glucocorticosteroids, but also nitroglycerin cream, isosorbide nitrate cream and other nitrate drugs. 3. Perianal eczema: for perianal eczema caused by anal itching, patients can follow the doctor’s instructions to use compound dexamethasone cream, florazepam ointment and other glucocorticosteroids, but also oral loratadine tablets, benadryl tablets and other anti-allergy drugs. Patients with symptoms of anal itching, may also be anal fissure, pinworms and other diseases, patients should consult a doctor in a timely manner, follow the doctor’s instructions for treatment.