Thyroid nodule grade III should be clear the nature of the nodule and then relevant treatment, can be through follow-up, drug treatment, surgical treatment, etc., specific treatment recommendations to consult a doctor. 1. Follow-up: Thyroid nodule grade 3 may be benign, malignant rate <2%, if there is no obvious discomfort symptoms, you can regularly follow up and review the thyroid ultrasound, no special treatment. 2. Medication: If thyroid nodule grade 3 is combined with hyperthyroidism or hypothyroidism, and the symptoms are stable, you can use levothyroxine tablets, methimazole and other drugs under the guidance of a physician for treatment. 3. Surgical treatment: If the thyroid nodule grade 3, and there is a significant increase or malignant tendency, may need to be clearly diagnosed through fine needle aspiration of the thyroid gland for thyroidectomy, microwave ablation and other surgical treatments. If there is a grade 3 thyroid nodule, it is recommended to go to a regular hospital for consultation, after a clear diagnosis, standardized treatment under the guidance of a physician, and do not take oral medication on your own, so as to avoid delays in the condition or adverse consequences.