Commonly used drugs for hypertension

  Commonly used drugs for hypertension treatment are: angiotensin converting enzyme inhibitors (ACEI), angiotensin receptor antagonists, calcium antagonists, diuretics, beta blockers, etc. The following are introduced separately: 1. Angiotensin-converting enzyme inhibitors (ACEI) and/or angiotensin receptor antagonists: namely, “priligy” and “sartan”, commonly used are captopril, ramipril, fosinopril, benazepril, valsartan. Clofentezan, Irbesartan, etc. The reason for introducing these two classes of drugs together is that they have similar effects and are especially suitable for patients with combined heart failure or combined heart valve insufficiency. The most common side effect of ACEIs is dry cough, while angiotensin receptor antagonists are less likely to cause dry cough. Common contraindications to these 2 classes of drugs are: hypotension, simple valvular stenosis, renal artery stenosis, severe renal insufficiency, etc.  2, diuretics: commonly used are indapamide (Shoubisan or sodium catalase), hydrochlorothiazide, spironolactone, such drugs can relieve dyspnea and edema symptoms of heart failure, so it is especially suitable for hypertensive patients with combined heart failure. However, it is necessary to prevent blood potassium abnormalities during use. Indapamide and hydrochlorothiazide can cause low potassium, so they can be used in combination with potassium-preserving drugs such as spironolactone, “priligy” and “sartan”. Spironolactone alone can cause high potassium, especially in patients with renal insufficiency.  Diuretics (mainly indapamide and hydrochlorothiazide) with ACEI, the combination of the two types of drugs, one is synergistic, more effective than a drug alone, the second is that some side effects can offset each other, the third is relatively inexpensive. For example, indapamide is paired with captopril, and even cheaper is hydrochlorothiazide paired with captopril. Salt-sensitive patients are suitable.  3, calcium antagonists: this class of drugs is one of the most widely used antihypertensive drugs, antihypertensive efficacy is also relatively strong, the most common side effect of this class of drugs is mild edema of the lower limbs. The most common side effects of these drugs are mild edema of the lower extremities. The most commonly used ones are: amlodipine, amlodipine (Loxodipine), and extended-release and controlled-release preparations of nifedipine. The most stable antihypertensive should be amlodipine, but the price is expensive.  4, beta blockers: such as metoprolol, bisoprolol, etc., this type of drug can slow down the heart rate, weakening the heart contraction force. Not suitable for patients with bradycardia, chronic bronchitis, severe heart failure, especially for those with exertional angina, and patients who have had myocardial infarction.  5, alpha blockers: generally used only for those with prostatic hyperplasia (because the drug has a symptomatic effect on prostatic hyperplasia), and pheochromocytoma combined with hypertension. Commonly used: prazosin, terazosin, etc. A common side effect is postural hypotension, i.e., hypotension that occurs easily when changing position too vigorously and should be noted in use. Terazosin can reduce this side effect when taken at bedtime.