Small itchy blisters on the fingers of the palms of the hands are usually caused by sweating herpes or tinea cruris, which is usually treated with topical medications plus oral medications. Sweat herpes is accompanied by symptoms of erythema and papules in addition to small blisters. Treatment of eczema can be oral antihistamines, such as loratadine, cetirizine, levocetirizine, ebastine and so on. Topical medications are preferred to glucocorticoid ointments, such as halometasone ointment, compound fluticasone ointment, fluticasone propionate ointment, and so on. Tinea cruris starts with pinpoint-sized blisters, which occur in clusters or scattered, and are accompanied by itching. You can take oral antiviral oral solution, ribavirin tablets, roxithromycin tablets, and apply terbinafine hydrochloride cream and clindamycin cream externally. Patients with small blisters on the palms of their hands with itching should go to the hospital and be examined by a doctor for a clear diagnosis and proper treatment.