Hand, foot and mouth disease is an enteroviral disease that occurs mostly in children under 5 years of age, is common in summer and autumn, and can be transmitted. The incubation period is usually 3-7 days, with no obvious prodromal symptoms: most patients have a sudden onset of disease. It mainly invades four areas: hands, feet, mouth and buttocks. The child salivates and refuses to eat due to painful mouth ulcers. Oral mucosal rash appears relatively early, initially as corn-like papules or blisters surrounded by a red halo, mainly on the tongue and both cheeks, and often on the lateral side of the lips and teeth. The rash is not itchy, and the papules turn from red to dark in about 5 days and then fade; the herpes is round or oval flattened and raised, with turbid liquid inside, with a long diameter in line with the direction of the skin lines, such as the size of a soybean, generally without pain and itchiness, and leaves no trace after healing. Hand, foot, and mouth diseases do not always appear in all cases in the same patient. The blisters and rash usually resolve within a week. Clinical features All cases have a rash with macules and herpes on the palms of the hands, feet, buttocks or knees. There is an acute onset of fever (rarely no fever); a painful, rice-grain sized, scattered herpes on the oral mucosa; rice-grain sized herpes on the palms of the hands or feet, and occasional involvement of the buttocks or knees. The herpes are surrounded by an inflammatory redness and the fluid inside the herpes is low. Some children may have a cough, runny nose, loss of appetite, nausea, vomiting, headache, etc. Doctors can usually differentiate HFMD from other causes of oral ulcers based on the patient’s age, the patient’s or parents’ complaints of symptoms, and examination of the rash and ulcers. A throat swab or stool specimen can be sent to a laboratory for viral testing, but viral testing takes 2-4 weeks to produce results, so doctors usually do not offer to do this test. Basis: Epidemiological data, clinical manifestations, laboratory tests, and pathogenic tests are required to confirm the diagnosis. HFMD is an infectious disease caused by several enteroviruses and mainly affects infants and children under 5 years of age and preschoolers. HFMD often manifests itself as small rice- or green-bean-sized, reddish, gray-white herpes or red papules on the cheek, tongue, soft palate, hard palate, inside of the lips, heart of the hands and feet, elbows, knees, buttocks, and forehead of the child. Treatment and prevention principles 1. In terms of treatment, the prognosis of this disease is generally good if there are no complications, and it is mostly cured within a week. The treatment principle is mainly symptomatic treatment. Chinese herbal medicines can be taken to clear heat and detoxify the body and dispel the symptoms. Herbal tea and allopathic treatment and prevention can be used. Vitamin B and C. Patients with comorbidities can be treated with intramuscular injection of propyl globulin. During the illness, the care of the child should be strengthened and oral hygiene should be done. Before and after eating, saline or warm water can be used to rinse the mouth, and non-irritating food such as liquid and semi-liquid is appropriate. Hand, foot and mouth disease can be combined with myocarditis, encephalitis, meningitis, chorioretinitis, etc., so we should strengthen the observation, do not take it lightly. 2, the principle of prevention: there is no vaccine for this disease. Strengthen monitoring, improve monitoring sensitivity is the key to control the epidemic of the disease. All localities should do a good job of reporting the epidemic, and child care units should do a good job of morning checks, timely detection of patients, collection of specimens, clear pathogenic diagnosis, and good disinfection of patients’ feces and their utensils to prevent the spread of the disease. During the epidemic period, parents should let their children go to crowded public places as little as possible to reduce the chance of infection. Hospitals should strengthen prevention by setting up special consultation rooms to prevent cross-infection. In areas where HFMD is endemic with serious comorbidities, frail infants and children who are in close contact with patients can be given intramuscular injections of propyl globulin. 3, prevention and control measures: hand, foot and mouth disease transmission channels, infants and children are generally susceptible. Good personal hygiene of children, families and child care institutions is the key to prevent infection of this disease. 4.Antibiotics have no therapeutic effect on the disease itself.