It is not necessary to administer Leuprolide for 28 days. The timing of the drug’s intramuscular injection, usually, every 28 days for adults, if there are special circumstances can be appropriate to advance or delay a few days, but should not be too long. Leuprolide is currently used for adenomyosis, ovarian chocolate cysts, uterine fibroids, prostate cancer, premenopausal breast cancer, and central precocious puberty. The drug is associated with adverse reactions such as edema, chest pressure, chills, malaise, numbness of the lips or limbs, and elevated blood sugar levels. A history of hypersensitivity to the components of this preparation, synthetic LH-RH or L-RH derivatives; pregnant women and women at risk of pregnancy or breastfeeding; patients with the presence of undiagnosed abnormal vaginal bleeding. If you need to take Leucovorin, it is recommended that you use the medication under the supervision of a doctor to avoid adverse effects.