Regardless of the treatment and rehabilitation, migraine is generally difficult to cure or completely eradicate. Most can only be treated symptomatically or as a palliative treatment. Partial relief of symptoms is very good. It is also recommended that patients avoid overwork, cold, fever, diarrhea and trauma as much as possible, and keep a calm mood to reduce the chance of recurrence. Exercise should be moderate, no need to practice too strenuous. If you smoke or drink alcohol, you should quit. If you have high blood pressure or diabetes, you should take medication regularly. The purpose of migraine treatment is to reduce or terminate the headache attack, relieve the accompanying symptoms and prevent the recurrence of headache. Treatment includes both pharmacological and non-pharmacological treatments. Non-pharmacological treatment is mainly physical therapy can be taken with magnetic therapy, physical therapy, oxygen therapy, psychological relief, stress relief, maintaining a healthy lifestyle and avoiding various migraine triggers. Pharmacological treatment is divided into treatment during the attack period and preventive treatment. In order to obtain the best treatment effect, medication should be taken immediately at the beginning of symptoms. Medications include non-specific analgesics such as non-steroidal anti-inflammatory drugs (NSAIDs) and opioids, and specific medications such as ergot agents and traptans. Drug selection should be individualized according to the degree of headache, concomitant symptoms and previous medications. 1. Mild to moderate headache: NSAIDs such as acetaminophen, naproxen and ibuprofen alone can be effective, and if they are ineffective, migraine-specific drugs should be used. Opioids such as pethidine are also effective for acute attacks of confirmed migraine, but because of their addictive properties, they are not routinely recommended for the treatment of migraine. However, in cases where ergot agents or traptans are contraindicated, such as combined heart disease, peripheral vascular disease or migraine during pregnancy, pethidine may be given to terminate acute attacks of migraine. Some of the temporary use of Somigel (common painkillers) is also effective. 2.Moderate-severe headache: Migraine-specific treatment drugs such as ergotamine and treprostatin can be used directly to improve the symptoms as soon as possible. Ergotamine (dihydroergotamine, DHE), which can terminate the acute attack of migraine. 2.Triptans: 5-HT1B/1D receptor selective agonists, probably by constricting cerebral blood vessels, inhibiting the neuropathic transmission of peripheral nerves and secondary neurons of the “trigeminal cervical complex”. It is usually effective when it is taken when there is an aura of headache or when there is a headache, but it is not effective when it is used after the headache starts. Therefore, it is the first choice for typical migraine with aura. Commonly used drugs include sumatriptan, naratriptan, rizatriptan, zolmitriptan, and almotriptan. Adverse effects of ergot and treprostatin drugs include nausea, vomiting, palpitations, irritability, anxiety, peripheral vasoconstriction, and large amounts of long-term application can cause hypertension and ischemic necrosis of the limbs. The above two classes of drugs have potent vasoconstrictive effects and are contraindicated in patients with severe hypertension, heart disease and pregnant women. In addition, if ergot and treprostatin drugs are applied too frequently, they can cause drug overuse headache. To avoid this, it is recommended to use the drugs no more than 2 to 3 days per week. 3. Concomitant symptoms: Nausea and vomiting are prominent concomitant symptoms of migraine and are also common adverse reactions of drugs, so it is necessary to combine antiemetic agents (such as metoclopramide 10mg intramuscular injection). For those who have irritability, benzodiazepines can be given to sedate and put the patient to sleep. Migraine prevention 1. Avoid headache triggers: To prevent migraine attacks, first eliminate or reduce the triggers of migraine, avoid the direct stimulation of strong light in daily life, such as avoiding looking directly at the reflection of car glass, avoiding looking out from a dark interior to a brightly lit exterior. Avoid looking at neon lights with strong light. Avoid taking medications such as vasodilators, drinking red wine and eating foods containing cheese, coffee, chocolate, smoked fish, etc. Avoid emotional tension, temper tantrums or ups and downs, overexertion, obvious lack of sleep, cold and flu, trauma, etc. 2.Medication: Prophylactic treatment is suitable for: (1) Patients with frequent seizures, especially those who have more than one seizure per week that seriously affect their daily life and work. (2) Patients for whom acute treatment is ineffective, or for whom acute treatment is not possible due to side effects and contraindications. (3) Special variant migraine that may lead to permanent neurological deficits, such as hemiplegic migraine, basal migraine or migrainous infarction. Prophylactic medication needs to be taken daily and the effect should be seen at least 2 weeks after administration. If there is an effect continue to take it for 6 months, then taper to discontinuation. Drugs used clinically for migraine prophylaxis include (depending on the individual): (1) beta-adrenergic receptor blockers, such as propranolol and metoprolol. (2) Calcium antagonists, such as flunarizine and verapamil. (3) Anti-epileptic drugs, such as valproic acid, topiramate. (4) Antidepressants, such as amitriptyline, fluoxetine. (5) 5-HT receptor antagonists, such as phenothiazine. Among them, propranolol, amitriptyline and valproic acid, three structurally unrelated drugs, are the main prophylactic drugs, and one drug is ineffective to choose another drug.