Cold, numbness and pain in the limbs – including cold and numbness in the limbs, as well as pain after limb activity. Pain after limb activity is also called intermittent claudication, that is, walking a distance after the emergence of muscle parts of the limb soreness and pain, standing and resting for a while can be relieved to continue to walk, and then walk a distance and then repeat the pain symptoms. In addition, if there is significant pain without activity, resting pain has appeared, which may indicate that the disease has developed seriously. The above symptoms suggest that you may be experiencing atherosclerotic occlusion of the lower extremities. Swelling of the limbs – Be especially alert to unilateral limb edema that decreases in the morning and worsens in the afternoon, or any kind of sudden swelling of the limbs. This is likely to be a venous thrombosis and requires prompt medical attention. Limb or toe ulceration – suffering from hypertension or diabetes mellitus in the elderly, because of accidental injuries occurring limb or toe ulceration, after 1 ~ 2 weeks can not be healed, it may be lower extremity atherosclerosis occlusion or diabetic foot manifestations. Weakened or absent pulse – healthy people can touch the obvious arterial pulsation on the wrist or the surface of the foot, if the pulsation is weakened or absent, there may be arterial stenosis or blockage. A throbbing mass – If a throbbing mass is palpated in the abdomen and the frequency of the beat is similar to the heartbeat, it suggests that an aneurysm may be present and should be treated promptly, as rupture can be life-threatening. There is vascular plaque – physical examination through ultrasound found that there is vascular plaque should be promptly treated. Plaque may cause organ infarction if dislodged. Mini-stroke vs. stroke – Sudden symptoms such as blurred vision in the eyes, impaired mobility of the upper or lower extremities, aphasia, and slurred speech, which can be recovered on their own, are called mini-strokes, but they are often precursors and danger signals of stroke – cerebral infarction. It is important to see a vascular surgeon in time to rule out carotid artery, vertebral artery or cerebrovascular lesions. Varicose veins – the limbs appear bruised and exposed, or even itchy, blackened, broken, and inflamed veins. Venous thrombosis – ultrasonography reveals venous thrombosis in the limb to see a vascular surgeon promptly to avoid dislodging the thrombus down the bloodstream to the pulmonary artery and fatal pulmonary embolism.