1, pay attention to the safety of the treatment of hepatitis B medication should first emphasize the safety of hepatitis B patients, the condition is easy to change, the course of treatment is long, it is difficult to achieve the therapeutic purpose of a single drug, now more than ever using a combination of treatments, the safety of the medication is the first and foremost. Years ago, a variety of hepatitis drugs used, later proved to be unsafe, such as adenosine, phosphonic acid, etc., may cause renal function damage. The current use of interferon and lamivudine, etc., also have serious safety risks, and may lead to exacerbation of the condition if they are used inappropriately, selected inappropriately, or discontinued without authorization. The same insecurity exists with Chinese medicines. Some herbs and Chinese medicinal preparations have been proven to have significant liver-damaging effects, for example, the herbs Cangzhi, Guanzhong, Lei Gongteng, Smallpox, Nutmeg, Mentha piperita, Neem, etc.; and proprietary Chinese medicines, such as Xiao Chaihu Tang, Compound Qingdai Pills, Anti-nuclear Tablets and Ke Yin Pills. Therefore, to avoid abuse and overdue, overdose, for folk remedies, prescriptions must be used with caution, in order to prevent poisoning. Patients with a history of drug allergy or allergy, once the drug liver damage, must terminate the use of the drug, and promptly go to the regular hospital for treatment. 2, the pursuit of effectiveness Now many of the old drugs for hepatitis B, such as oral panciclovir, acyclic guanosine and so on have been proved to be ineffective, and are now gradually eliminated. At present, as the main drug for the treatment of hepatitis B – anti-hepatitis B virus drugs, recognized only interferon, lamivudine and other kinds of drugs, other drugs labeled with anti-hepatitis B virus nature, has not yet been unanimously recognized. In addition, hundreds of so-called “hepatoprotective drugs”, only some of them have the effect of improving liver function and reducing liver inflammation. Therefore, patients must choose the medication carefully and must not be rash and reckless, and must not trust the advertisements and other propaganda. 3, advocate economic treatment of hepatitis B costly, expensive drugs is well known, hepatitis B patients, the condition of capricious, medication, many patients due to poverty. Therefore, hepatitis B patients with medication must be carefully calculated, less money. For example, there are a lot of drugs with the function of hepatoprotective and enzyme-lowering, and when choosing drugs, we must take into account the affordability, compare and contrast, and choose inexpensive and good quality drugs, such as Ganlixin injection. Many new drugs have undetermined long-term efficacy, plus the price is very expensive, should not be recommended as a first-line drug trial. 4, grasp the appropriateness of rational use of drugs appropriate principle is mainly embodied in the following aspects: appropriate drugs according to the disease and the patient’s physical conditions, weighing a variety of factors pros and cons, choose the most appropriate drugs of the same type of drugs. For example, for patients with early cirrhosis, selecting antiviral combined with anti-hepatic fibrosis drugs for simultaneous use has the best efficacy. Appropriate dosage of interferon for the treatment of hepatitis B is very common, and the dosage is very delicate. If the dose is too small, it is difficult to work; if the dose is too large, the drug toxicity is too strong, the patient’s body is difficult to bear. It is generally believed that the appropriate dose for Chinese people is 5 million to 6 million units / every other day 1 time use. Appropriate time such as long-acting interferon used once a week can ensure that the concentration of the drug in the patient’s blood basically stays within the effective range within a week, which can reduce pain and trouble for the patient. The appropriate route of administration must take into account the purpose of the drug, the nature of the drug, the physical condition of the patient, as well as safety, economy, simplicity and other factors. Oral administration is convenient, economical and less painful for patients, on the contrary, intravenous drip is not advocated to be used easily. Appropriate patient treatment of hepatitis B emphasizes the principle of individualization and treatment according to the patient, such as interferon treatment, must require the condition of patients with elevated aminotransferases and positive replication index of hepatitis B virus; interferon treatment is not suitable for patients with severe or heavy hepatitis B. Appropriate course of treatment in accordance with the principles of therapeutics, the prescribed cycle of drug treatment. Both anti-hepatitis B virus treatment and anti-hepatitis fibrosis treatment require long-term perseverance; when the efficacy is obvious, the medication should not be stopped without authorization, and the treatment should be prolonged if necessary in order to obtain stable and long-lasting efficacy. For example, the treatment of hepatitis B with lamivudine and interferon requires a course of treatment of more than 1 year. However, some drugs should not be used for a long time, to avoid prolonging the administration time, to reduce the accumulation of toxicity, viral resistance, drug dependence and other adverse reactions. For example, once hepatitis B patients have a cold and fever, the use of anti-inflammatory drugs must be taken “short and fast” principle, so that the disease is removed from the drug stop.