Parkinson’s disease insomnia, the main drugs include benzodiazepine agonists, non-benzodiazepines, melatonin tablets and antidepressants, should consult a physician to guide the use. 1. Benzodiazepines such as diazepam, clonazepam, clonazepam, eszopiclone, etc., have certain hypnotic, anxiolytic, antispasmodic and muscle relaxant effects, which can shorten the time to sleep and reduce the duration and frequency of awakenings. Adverse effects include daytime sleepiness, dizziness, decreased muscle tone, falls, and cognitive impairment. It is contraindicated in women who are pregnant or lactating, those with hepatic or renal impairment, and those with severe ventilatory deficits. 2. Non-benzodiazepine drugs, including zolpidem, dexzopiclone, zaleplon, etc., have certain hypnotic effect, but no muscle relaxation and anticonvulsant effect; adverse reaction is that long-term use of drug dependence and drug rebound; prohibited in pregnancy or lactation of women and the allergic to this type of drug crowd. 3. Melatonin tablets can regulate circadian rhythm disorder sleep disorders; adverse effects of long-term use of drug dependence and drug rebound; prohibited in pregnancy or lactation of women and allergic to this type of drug crowd. It is worth noting that sleeping drugs have certain side effects and contraindications, and Parkinson’s disease patients with individual differences, involving specific treatment and medication, need to be under the guidance of a professional doctor.