(Disclaimer: This article is only for scientific purposes, in order to protect the patient’s privacy, the relevant information in the following content has been processed) Abstract: The patient’s subacute onset of disease, manifested as limb shaking, limb strength is still okay, accompanied by limb stiffness, walking forward leaning, at first did not pay attention to the patient, and then progressive aggravation to the clinic, combined with the head magnetic resonance and examination of the consideration of Parkinson’s disease, which belongs to a type of central nervous system disorders, the given Drug therapy anti-Parkinson’s disease and improve microcirculation, discharge symptoms slightly relieved, the patient’s condition is stable. Basic information] Female, 74 years old [Type of disease] Multiple lacunar cerebral infarcts, Parkinson’s disease [Hospital] The Second Affiliated Hospital of Harbin Medical University [Date of consultation] January 2022 [Treatment plan] Medication (Ginkgo biloba tablets, tetracosactyl monosialoglucosan ganglioside sodium injection, dobazepine tablets, atorvastatin calcium tablets) [Treatment period] Hospitalization for 6 days, regular outpatient follow-up [Treatment effect] Shaking symptoms of the limbs and improvement of microcirculation, the patient was discharged with stable condition. Treatment effect] The symptoms of limb shaking were relieved, the condition stabilized, and the patient was successfully discharged from the hospital. The patient was admitted to the hospital 6 months before the emergence of limb shaking without any obvious triggers, which manifested itself as obvious shaking at rest, aggravated by nervousness, alleviated by resting, and disappeared after going to sleep, accompanied by numbness of the limbs, no speech clumsiness, and no weakness of limbs, and the symptom was persistent, which was not given special attention at that time. Two weeks before admission, the above symptoms aggravated, walking small broken steps, with the body leaning forward, almost fell, turn around difficulties, so came to our hospital, see this kind of patients to my first impression is Parkinson’s disease, for further diagnosis, then arranged for the patient to be admitted to the hospital, we learned that the patient’s previous physical health, no encephalitis, brain injury, cerebral hemorrhage, cerebral infarction, and other underlying brain diseases. The examination showed: stable vital signs, blood pressure of 140/90mmHg, heart rate of 67 beats/min, general condition was OK; specialist examination: clear, speech was OK, bilateral pupils were equal to the same circle, diameter of about 2.5mm, no nystagmus, symmetry of the teeth, tongue extension was centered, static tremor of the hands, rubbing pills, muscle strength of the limbs was 5, muscle tone of the limbs was elevated, knee tendon reflexes of the bilateral sides were symmetrical, bilateral lower limbs were negative; cephalomagnetism was negative; head magnetism was negative; head magnetism was negative. Pathologic signs were negative; head magnetic resonance showed: multiple lacunar cerebral infarcts, geriatric cerebral changes. Ginkgo biloba was given to improve circulation, tetrahexose monosialate ganglioside sodium injection was given to nourish the nerves, dobasic hydrazide tablets were given orally to fight against Parkinson’s disease, atorvastatin calcium tablets were given to lower blood lipids and stabilize plaque, and close attention was paid to the patient’s mental health during the treatment period. The above is the result of head magnetic resonance (the patient has obvious blood vessel stenosis, the white color in the above picture is the blood flow, and the place not shown is considered to be the blood vessel stenosis). The patient was healthy in the past, and through the drug treatment for 6 days, the patient’s symptoms of limb trembling and stiffness were relieved, and the symptoms of difficulty in turning over and turning around at night were also improved; however, the relief of the above mentioned symptoms was slower, but on the whole, the patient’s disease regression was good, and his condition tended to be stabilized. Parkinson’s disease is a chronic progressive disease, fully and the patient’s family to explain the condition, this disease can not be cured, the late need for uninterrupted oral drug therapy, and observation of the symptoms of the review and adjustment of medication, the patient met the discharge criteria, continue anti-Parkinson’s disease treatment, while given to regulate blood lipid therapy, later told the patient to avoid eating too greasy food, drink plenty of water to ensure adequate sleep, 1-2 months follow-up, outpatient clinic after the body examination Adjust the dosage of anti-Parkinson’s disease drugs. Fourth, precautions We are glad that the patient’s symptoms have improved after treatment, but at the same time to remind the patients with Parkinson’s disease need long-term oral drug therapy, the patient orally dopa-serine tablets, starting from a small dose, generally need to closely observe the patient’s symptoms, signs and symptoms, and regularly adjust the anti-Parkinson’s disease drug dosage and frequency, if the effect of one kind of drug is not good, then you need to add the drug, the principle of medication is to achieve the goal of effective improvement of symptoms, improve the ability to work and quality of life. The principle of medication is to achieve the goal of effectively improving symptoms, work ability and quality of life. In addition, Parkinson’s disease patients are prone to poor mood, insomnia, anxiety and depression, etc., the patient’s family members should actively carry out family counseling, if necessary, assisted by anti-anxiety, antidepressant drugs to improve sleep therapy, and later on, can be psychological counseling psychiatry clinic. Fifth, personal perception By understanding the patient’s case, we can see that Parkinson’s disease is an incurable disease, with time, the symptoms may be more and more serious, generally start more single-drug therapy, but also can be a small dose of the two drugs used in combination, the early symptoms are not obvious may be able to continue to go to work, and the patient is often combined with emotional instability, irritability, poor sleep and other psychiatric and psychological problems, these symptoms will be gradually highlighted, and the later get up and down to the ground activities Difficulty in getting up and down, only bedridden. In addition, patients with Parkinson’s disease need to be reminded to differentiate from Parkinson’s syndrome, progressive supranuclear palsy and other diseases.