For the occurrence of Parkinson’s disease, it is considered that there is a relationship with the degenerative death of nigrostriatal dopaminergic neurons, but it is not clear the specific cause of the degenerative death of nigrostriatal dopaminergic neurons.
Movement is governed by a range of neurological functions, and most dyskinesias are associated with lesions of the basal ganglia, which consists of the caudate nucleus and the substantia nigra. Abnormalities in the activity of this circuit, such as lesions of the substantia nigra-striatal dopaminergic pathway, can lead to an increase in the output of the basal ganglia, resulting in Parkinson’s disease.
The cause of death from nigrostriatal dopaminergic neuron lesions is still unclear, and is considered to be due to a variety of factors such as environmental factors, genetic factors, neurologic aging, and multifactorial interactions.
1. Some industrial or agricultural toxins cause free radical production and oxidative stress causing degenerative loss of dopaminergic neurons.
2. Studies have shown that 10% of Parkinson’s patients have a family history of the disease.
3. Ageing, neurologic aging and morbidity can lead to progressive reduction of nigrostriatal dopaminergic neurons, causing Parkinson’s.
4. Some patients with Parkinson’s are affected by a large number of degenerative losses of nigrostriatal dopaminergic neurons caused by a combination of factors.
The onset of Parkinson’s is complex and should be treated aggressively if diagnosed.