Does alcohol cause cancer?

Alcohol is a Group 1 carcinogen. Alcohol is defined as a Group 1 carcinogen by the World Health Organization’s International Agency for Research on Cancer (IARC), but Group 1 carcinogens do not necessarily cause cancer in individuals, and the cause of cancer is currently unknown. Based on population-based studies across world regions and genders, 4.1% of all new cancer cases in 2020 could be attributed to alcohol consumption, involving more than 740,000 cases, of which men account for 76.7%. Common tumors such as esophageal cancer, liver cancer, breast cancer, oral cavity cancer, pharyngeal cancer, and stomach cancer are all associated with alcohol consumption. Although the mechanism of action of alcohol in causing cancer has not been clearly concluded, one important way is that its metabolite acetaldehyde damages DNA. After drinking, alcohol will be absorbed in the gastrointestinal tract, and the incompletely absorbed alcohol will be decomposed into acetaldehyde in the liver under the action of ethanol dehydrogenase, and acetaldehyde will be decomposed into acetic acid under the action of acetaldehyde dehydrogenase and enter the tricarboxylic acid cycle and decompose into carbon dioxide and water. If you drink a lot of alcohol over a long period of time, the decomposition of alcohol into acetaldehyde can not be metabolized by the liver in a timely manner, may lead to a large amount of accumulation of acetaldehyde in the body, due to the ability of acetaldehyde to bind to DNA leading to genetic mutations, but also the body of the liver, esophagus and other parts of the apoptosis, inducing chronic inflammation, thereby increasing the risk of cancer. In conclusion, it is recommended to abstain from alcohol. If you experience any discomfort, it is recommended that you go to a specialized hospital for further examination and treatment under the guidance of a doctor after the cause of the disease has been identified.