Whether urinary protein 2+ is serious or not needs to be judged on a case-by-case basis. Pathologic factors such as glomerulonephritis are more serious; if it is caused by urinary tract infection, it is usually not serious. If it is caused by physiological factors such as strenuous exercise, it is usually not serious. 1. Glomerulonephritis: when caused by glomerulonephritis, it is more serious. It can manifest as proteinuria, hypertension, renal insufficiency and so on. Mainly due to the increase in capillary permeability of the glomerulus, protein leakage, can improve the renal puncture biopsy, clear pathology type, follow the doctor’s instructions to take valsartan, prednisone acetate and other drugs for treatment, in severe cases, there may be uremia. 2. Urinary infection: when patients with urinary infection, if the destruction of urinary tract epithelial mucosa, at the same time due to some patients may have fever symptoms, which leads to increased glomerular permeability caused by protein leakage, in the urine routine examination will appear in the urine protein 2 + symptoms. Follow the doctor’s instructions to carry out anti-infection treatment (such as amoxicillin), generally can return to normal. 3. strenuous exercise: when the patient after strenuous exercise, easily lead to renal vasoconstriction caused by insufficient blood supply, resulting in protein leakage caused by the urine protein 2 + situation, usually belong to the normal physiological phenomenon, usually within a few hours of rest will disappear and return to normal, so this kind of urine protein is not serious. The 2+ urine protein patients should be timely to the hospital for relevant examination, clear cause, under the guidance of the doctor for targeted treatment.