The endometrium will be thickened in 1-3 months after taking Tonicare, but the exact time of thickening varies because the specific conditions of each patient are different. Tonicare belongs to the estrogen class of drugs, the main ingredient is estradiol valerate, after taking it can replenish the body’s estrogen, commonly used in the treatment of menopausal syndrome or due to various causes of ovarian secretion of estrogen decreased supplement. Under normal physiological conditions, after the end of menstruation, the level of estrogen in the body will gradually increase, so that the endometrium will begin to thicken, and the thickness of the endometrium in the ovulation period of 8-13cm is normal. In some patients, due to endocrine disorders, low estrogen secretion or excessive scraping, etc., the endometrium is thin, so that the menstrual flow is reduced, which affects normal fertility, can be thickened by taking Supplemental Jiale to thicken the endometrium, so that menstruation is normal and conducive to conception.