People who fall into the spiral of depression invariably feel low, depressed, unmotivated, and see the world in their eyes as gray, without a glimmer of light, without a future and without hope ……. The physical condition of the patient is generally healthy (although most people consider themselves to be in extremely poor health). As a result, it is customary to think of this as a heart condition and often give the patient some psychological comfort and persuasion (the most common method is “you should think about it”), although these are not very helpful. Wu Zhiguo, a psychiatrist at the Shanghai Mental Health Center, said that for this heart disease, with the availability of effective antidepressants, is it better to treat it medically or psychologically? In fact, from the point of view of the etiology of depression, it is usually promoted by both the internal environment (biological factors) and the real environment (psycho-social factors) of the patient. For the internal environment, it is very difficult for us as biological individuals to overcome it by our own efforts alone, which naturally requires the help of antidepressant drugs (or other physical therapies) with biological effects. Of course, drugs are never a panacea, because there are no people in the world who live in a purely internal environment. Some real-life environmental stimuli are often important contributing factors to depression, and even without real-life triggers, there are many psychological conflicts within the depressed person that cause inappropriate perceptions of reality, which medications do not yet seem to be able to address. As the saying goes, the heart has to be cured, and psychotherapy is essential to treat depression. Giving patients active and supportive psychotherapy helps them face the reality of their situation and accept it as it is, and although this is difficult to do, facing it is far more helpful than avoiding it. When available, patients should also receive more intensive psychotherapy, discussing with the psychiatrist the underlying psychological causes of depression, changing maladaptive cognitions and negative behaviors, and even changing aspects of their personality that do not fit, which are beyond the power of medication. For individual patients, there is no difference between the advantages and disadvantages of psychological and pharmacological treatments, and a two-pronged approach is the best choice.