Carboplatin, cisplatin and loplatin all belong to platinum agents, among which cisplatin is the representative of the first generation of platinum agents, carboplatin is the representative of the second generation of platinum agents, and loplatin belongs to the third generation of platinum agents. The main differences among them are as follows: 1. Different anti-tumor spectrum. Although all three platinum agents are broad-spectrum antitumor agents, firstly, cisplatin has the broadest antitumor spectrum and can be used for the treatment of a variety of malignant tumors. The second is carboplatin, and loplatin is mainly used for the treatment of breast cancer, small cell lung cancer, chronic granulocytic leukemia and other malignant tumors. 2. The degree of side effects leading to vomiting is different. The vomiting effect of carboplatin is weaker than that of cisplatin, but it is significantly stronger than that of loplatin. 3. The side effects of bone marrow suppression are different. The side effects of carboplatin and loplatin are stronger than those of cisplatin, especially loplatin, which has a strong inhibitory effect on platelet production and should be used with special attention. 4. The toxicity to the kidneys is also different. Cisplatin has obvious toxicity to the kidneys, which can lead to renal failure in serious cases, which is a serious side effect. Therefore, it is necessary to alkalize and hydrate the urine during use, which means that a large amount of fluid and alkali should be replenished during chemotherapy to make the urine alkaline to facilitate the excretion of cisplatin metabolites out of the body. Carboplatin and loplatin have minimal nephrotoxicity and do not require hydration or alkalinization.