Colposcopy low-grade lesions how to do need to refer to the patient’s specific condition, some patients can be followed up regularly, some patients need surgical treatment. Colposcopy for low-grade lesions, suggesting that the patient’s cervical squamous epithelial cells there is a mild disorganization of the nucleus, there is a heterogeneous, confined to the subepithelial one-third of the cervical epithelial cells, at this time the patient should be examined for p16 staining, such as the examination is negative, the patient’s regular follow-up can be about 60% of the natural regression. If the patient’s p16 staining is positive, the lesion persists during clinical follow-up, and the condition of some patients even develops further, at this time, there is a risk of cancer, and surgery should be performed as early as possible. Therefore, when abnormalities appear in patients’ examination, they should receive guidance and treatment from professional physicians in time to avoid delaying the condition and leading to adverse consequences.