Statins are among the most widely used drugs for cardiovascular applications. Statins, which are suitable for hypercholesterolemia and mixed hyperlipidemia with mainly elevated cholesterol, are the most comprehensive lipid-lowering drugs and the first choice for lipid-lowering recommended by guidelines. Moreover, it can delay atherosclerosis, reduce the incidence of cardiovascular diseases, and comprehensively prevent and treat coronary heart disease, myocardial infarction, stroke and other cardiovascular and cerebrovascular diseases. However, it is understood that from small clinics to large tertiary hospitals, from cardiology to neurology, the majority of doctors are accustomed to giving statins at night; is it justified to do so? 1, statin lipid-lowering drugs classification (according to the length of the half-life): 1) short-acting class statin: such as simvastatin, pravastatin, fluvastatin, lovastatin, blood lipid Kang, etc.; 2) long-acting class statin: such as atorvastatin, resulvastatin, pitavastatin, fluvastatin sodium extended-release tablets. 2, statin lipid-lowering drugs mechanism of action Synthesis of cholesterol is a rate-limiting enzyme called hydroxymethylglutaryl coenzyme A reductase, this enzyme is most active at night, that is to say, the highest activity at night, statins are precisely competitive inhibition of this rate-limiting enzyme to play a lipid-lowering effect. This shows that the key to the problem is the half-life of statins. If a statin is taken at night, the plasma elimination half-life is several hours, and the peak blood concentration is reached in the middle of the night, so that the best effect can be achieved. Several studies have been done in this area, and for simvastatin, lovastatin, pravastatin, and cerivastatin, nighttime administration is superior in efficacy (greater reduction in total cholesterol or LDL-C) to varying degrees compared to morning administration. For the long-acting drugs: atorvastatin and rasulvastatin, there was no difference in efficacy between morning and nighttime dosing. Interestingly, atorvastatin blood levels were lower when given at night, with peak blood levels 30% lower at night than in the morning, which may be related to less absorption due to weak gastrointestinal activity at night, or faster metabolism at night. It is clear that atorvastatin and resevastatin do not need to be taken at night. In fact, a careful review of the instructions for both drugs specifically states that they “can be given at any time and are not affected by eating”. In addition, when statins are not primarily used to lower cholesterol, but to stabilize the lining of blood vessels and to combat inflammation, theoretically they should have the same effect when taken orally at any time of the day. However, this situation can be equally effective when taken at night. 3.In summary, the following 3 points are summarized for your reference: 1）For statins with short half-life such as lovastatin, simvastatin, pravastatin and fluvastatin, they can be administered at bedtime, thus reaching the peak of drug concentration at the peak of cholesterol synthesis at night and exerting greater therapeutic effect. (2) For statins with long half-life, such as pitavastatin, atorvastatin, and resevastatin, they can be taken at any time of the day, but they should be taken at regular and fixed times. (3) For statins with short half-life, slow and controlled release formulations such as fluvastatin sodium extended release tablets can be taken at any fixed time of the day. Therefore, some statins need to be taken at night and some do not need to be taken at night, mainly because of the half-life of the drug, or the drug formulations such as slow and controlled release formulations.