Elevated sm accumulation is defined as 4-6 times normal SM accumulation and normal enzyme activity. Niemaoh-Pick disease (NPD), also known as sphingomyelin lipidosis, is a group of lysosomal storage diseases with abnormal lipid metabolism and is a congenital glycolipid metabolic disease. It manifests as an elevated accumulation of serum mucin (SM). Niemann-Pick disease (neurosphingolipid storage disease) is caused by abnormal neurosphingolipid metabolism due to mutations in genes such as sphingomyelin phosphodiesterase, resulting in excessive lipid accumulation in the liver, kidneys, spleen, bone marrow, and brain of the patient, and causing lesions in these organs. Niemannpick’s disease (neurosphingolipid storage disease) is autosomal recessive. Niemannpick’s disease is characterized by a large number of foamy cells containing neurospherin in all mononuclear macrophages and the nervous system. It is more prevalent in Jews, with a prevalence of 1 in 25,000. there are at least five types. So how is the prevention and treatment of elevated sm accumulation? Here’s a look at it. No special treatment, symptomatic treatment, attached fat diet, strengthen nutrition. 1, antioxidants: vitamin C, E or butylated stilbene, can stop the peroxidation of unsaturated fatty acids contained in the neurospinal phospholipids M and poly and reduce the formation of lipofuscin and free radicals. 2.Splenectomy: suitable for non-neurological type with hypersplenism. 3.Embryonic liver transplantation: successful results have been reported.