Elevated SM accumulation is defined as 4 to 6 times normal SM accumulation with normal enzyme activity. Niemaoh-Pick disease (NPD), also known as sphingomyelin lipidosis, is a congenital disorder of glycolipid metabolism. It is characterized by a large number of foamy cells containing neurosphingomyelin in all mononuclear macrophages and in the nervous system. It is less common than Gaucher’s disease. It is autosomal recessive and is more prevalent in Jews with an incidence of up to 1/25,000. there are at least five types. So what are the preventive measures for elevated sm accumulation? Here’s a look at them. The preventive measures for elevated sm accumulation 1, elevated sm accumulation is due to neurophospholipase (sphingomyelinase) deficiency. Familial disorders of lipid-like metabolism. This disease is autosomal recessive, most patients are parents of consanguineous marriage, according to this situation, can strengthen the “ban on consanguineous marriage” from the perspective of the strict implementation of the marriage law to reduce the incidence of this disease, and effectively improve the physical quality of our people. 2, has been diagnosed with elevated A or B sm accumulation (neurospherin storage disease), the mother should be prenatal diagnosis when pregnant again. 3. There is no treatment for elevated sm accumulation. Scientists are further investigating the biochemical mechanism and pathology of the disease in the hope of developing treatments such as bone marrow transplantation, enzyme replacement therapy and gene therapy.