Cholestasis syndrome is a condition in which the flow of bile is blocked from flowing into the digestive tract for various reasons both inside and outside the liver, causing the bile components to stagnate in the hepatobiliary system or enter the bloodstream, causing damage to the body resulting in jaundice, deepening of the color of the urine, lightening of the color of the feces, and generalized itching, among other related symptoms. The causes of cholestasis are categorized as intrahepatic and extrahepatic. Intrahepatic causes include acute hepatitis, alcohol-related liver disease, primary biliary cholangitis, cirrhosis due to viral hepatitis, cholestasis of pregnancy due to the effects of certain medications or hormones on the flow of bile during pregnancy, and cancer that has spread to the liver. Extrahepatic causes include bile duct stones, bile duct strictures, bile duct cancer, pancreatic cancer, and pancreatitis. All of these causes cause cholestasis to varying degrees. When bilirubin, a component of bile, is deposited in the skin, it causes a yellowing of the skin and sclera; when the kidneys excrete too much bilirubin, it causes a deepening of the color of the urine; when bilirubin’s access to the intestinal tract is blocked, preventing it from being excreted from the body into the feces, the feces become lighter in color; and the bile products that are retained in the skin can cause itching. In addition, bile helps to digest fats in food and promotes the absorption of calcium and vitamin D. Cholestasis can lead to deficiencies in fats that are difficult to digest and nutrients that are impaired in absorption. Patients with cholestasis syndrome should receive standardized treatment under the guidance of a doctor, who will give a treatment plan based on a comprehensive diagnosis of the cause of the disease based on symptoms, signs and auxiliary test results.