Impotence and premature ejaculation are common urological disorders and are the two most predominant male sexual dysfunctions. Oral medications are the simplest and the most acceptable first-line treatment for impotence and premature ejaculation for patients. Impotence is now also known as erectile dysfunction, and a common drug used for treatment is PDE5 inhibitors, commonly used drugs mainly include sildenafil, which is often referred to as Viagra by the people. Also now commonly used include tadalafil, taking this drug must be careful not to eat at the same time nitrate vasodilator drugs, such as common cardiac pain, etc., otherwise it is easy to have a drop in blood pressure and dangerous. The main drug for treating premature ejaculation is Dapoxetine, also known by its trade name, Bilirim, which is the only drug approved and recognized for the treatment of premature ejaculation. It is a 5-hydroxytryptamine reuptake inhibitor and is also taken on demand, 1-3 hours before intercourse. Other antidepressants, such as sertraline, this drug requires long-term use and has slightly more side effects than piritin.