Patients with thigh and calf muscle pain and weakness may first be caused by overexertion. If a patient who usually lacks exercise suddenly performs some high-load labor or strenuous sports, it may cause the body to produce anaerobic enzymes, thus producing a large amount of lactic acid, and the accumulation of lactic acid in the muscles of the whole body may lead to the symptoms of muscle soreness. In addition, viral infection may also cause muscle pain in the limbs, such as patients with viral colds, in addition to coughing, sneezing, nasal congestion and other symptoms of the common cold, there may be muscle pain in the limbs, weakness and other symptoms. In addition, muscle soreness in the thighs and calves may also be caused by cold, such as prolonged exposure to air conditioning or rain, which may also cause symptoms of muscle soreness in the limbs. In this case, first of all, we should pay attention to rest and avoid strain, in addition, we can use some anti-inflammatory and pain-relieving drugs for symptomatic treatment to relieve the symptoms of pain.