Stabbing pain in the thighs like pins and needles can be caused by the following reasons: first, history of varicose veins, thrombophlebitis, localized redness and swelling, and masses, tenderness, recurrent varicose veins in the lower limbs, swelling of the lower limbs after activity, which should be treated surgically. Secondly, lower limb infection, especially dengue, secondary to streptococcal infection, manifested as patchy red and swollen changes in the lower limbs, pinprick-like pain, also accompanied by fever, should be anti-inflammatory treatment, and at the same time can be applied externally to the trauma magnesium sulfate, can relieve the condition. Third, some patients are caused by lumbar disc herniation, nerve root compression will appear abnormal sensation in the lower limbs, tingling pain, and in severe cases, lower limb movement will be limited.