Cold medicines are all proprietary Chinese medicines or allopathic supportive medicines, which generally do not affect vaccination, so taking cold medicines does not affect vaccination. However, the cause of the child’s cold itself may affect the vaccination, especially if the child is in the period of acute cold, with fever, cough obviously, or vomiting, diarrhea and other acute its symptoms, which is not suitable for the hepatitis B vaccination. It is recommended that the vaccine be given after 1 week of recovery from acute illness. Because vaccination during acute cold may not have the immunological effect that vaccination should have, and it also tends to cause the aggravation of cold symptoms, because the body has to produce an immune response after vaccination, which will have a certain degree of impact on the child’s own cold.