The causes of sudden knee pain include soft tissue injury, gout, knee arthritis, etc. General treatment, medication and surgery can be chosen to relieve the pain according to different causes. 1. Soft tissue injury: If the knee joint is under high workload for a long time, it will make the soft tissues suffer from repeated pulling and squeezing, which in turn will cause soft tissue injury and the problem of knee pain. The affected limb can be elevated and immobilized to reduce swelling. If the pain is more intense, you can also use topical diclofenac sodium ointment, or oral painkillers such as ibuprofen, diclofenac sodium and other drugs to relieve. 2. Gout: Gout is closely related to hyperuricemia, and knee pain will occur during an attack. You can use allopurinol, febuxostat and other drugs to lower uric acid treatment. When the pain is severe, painkillers such as indomethacin and diclofenac can be used. If the formation of gout stone affects the function of the joint, you can consider the implementation of surgery to remove the gout stone and correct the knee joint. 3. Knee osteoarthritis: The cause of knee osteoarthritis is unknown, but it is closely related to age, heredity and obesity. Topical flurbiprofen gel can be used, or oral analgesic drugs such as celecoxib can be taken. If necessary, the disease can be eliminated through surgery, such as knee replacement. There are many reasons for sudden knee pain, the pain is mild can be temporarily observed, if the pain is serious and timely medical examination, and according to the doctor’s instructions, targeted treatment, do not blindly use drugs.