If your heart is uncomfortable after staying up late, you need to consider whether it is a neurological disorder. In this case, you can use drugs to regulate neurological disorders to relieve, such as glutamatergic or antidepressant Chinese medicine, or you can also take oral sedative drugs such as eszopiclone. Patients are recommended to develop good sleep habits and pay attention to the combination of work and rest, avoid staying up late, and avoid eating spicy and stimulating food before going to sleep, and avoid eating too much. Staying up late for a long time may have an effect on the blood supply to the heart muscle and can cause arrhythmias. If necessary, patients need to go to the hospital for electrocardiogram, ambulatory electrocardiogram, cardiac ultrasound and other examinations, and use relevant drugs for symptomatic treatment under the guidance of doctors. For people who have neurasthenia and poor sleep quality, they should not stay up late to avoid aggravating their condition.