Blood sugar can not come down can be injected insulin as needed to control blood sugar, need to be under the guidance of a doctor. Diabetes treatment should follow the principle of individualization, and it is currently believed that insulin injection is recommended to control blood glucose in patients with type 1 diabetes as well as type 2 diabetes in special cases. 1. Type 1 diabetes: insulin therapy should be started as soon as diagnosed and lifelong replacement therapy is required. 2. Type 2 diabetes mellitus by lifestyle intervention and larger doses of a variety of oral hypoglycemic drugs combination therapy, blood glucose still does not meet the control goals; in the course of diabetes, the emergence of no obvious cause of significant weight loss; on the symptoms of significant, blood glucose significantly increased the newly diagnosed type 2 diabetes mellitus, the diagnosis can be considered at the time of insulin therapy can be combined with or without the use of their medications. The type of insulin can be selected according to the patient’s specific situation. Diabetic patients whose blood sugar does not come down after diet, exercise and oral hypoglycemic drugs should consult a professional physician to develop the next step.