Hard large pimples may suggest suffering from common warts, nodular itchy rash, infectious molluscum contagiosum, folliculitis and other diseases, need to be based on the specific situation of physical therapy, drug treatment, surgical treatment and so on. 1. common warts: due to the infection of human papilloma virus caused by the fire needle acupuncture and other ways to make warts necrosis, off, but also under the guidance of the doctor to apply recombinant human interferon ointment and other treatments. 2. nodular itchy rash: the treatment can choose to freeze and other ways to make the nodules necrosis, off, but also under the guidance of the doctor to use a strong glucocorticoid ointment, such as fluticasone propionate cream and other treatment. 3. Molluscum contagiosum: in the treatment can be applied to ionized cauterization, wart scraping and other treatments, if the situation has not been relieved, it is recommended to go to the hospital in a timely manner, under the guidance of the doctor surgical excision of warts and other ways of treatment. 4. Folliculitis: Depending on whether it is a bacterial or fungal infection, anti-infective treatments such as mupirocin ointment or anti-fungal treatments such as terbinafine cream can be given. The hard large pimples, you need to actively consult the doctor, follow the doctor’s instructions reasonable treatment, drugs need to be under the guidance of the physician reasonable application.