Women with abnormal uterine bleeding, infertility, and diagnosis of endometrial disease require endometrial biopsy. 1. Abnormal uterine bleeding: Abnormal uterine bleeding at any age, along with high risk factors for endometrial hyperplasia, requires an endometrial biopsy to identify the cause of the abnormal bleeding. 2. Infertility: To treat infertility and to determine the presence or absence of ovulation and luteal insufficiency, an endometrial biopsy is often required to determine the next step in treatment. 3. Diagnosis of endometrial diseases: such as endometrial hyperplasia or endometrial lesions that cannot be excluded, endometrial polyps, submucosal fibroids, endometrial tuberculosis, etc., endometrial biopsy is required, and then decide on the treatment plan based on the results of the biopsy. It should be noted that for women of childbearing age, pregnancy-related bleeding must be ruled out before performing endometrial biopsy, and it is also recommended that patients must cooperate with the doctor’s treatment after endometrial biopsy if organic diseases are considered. Normally, if there are any abnormalities such as irregular bleeding, it is important to follow up promptly.