Cowden syndrome is a disorder in which the body develops misshapen or chemotactic lesions, also known as multiple misshapen syndrome. It is a dominantly inherited disease caused by mutations in genes and is characterized by complex and variable signs and symptoms. 1. Causes: Mutations in the PTEN gene lead to excessive proliferation of mutated cells that cannot be killed by PTEN, resulting in the formation of a misshapen tumor. 2. Clinical symptoms. The most obvious feature of the clinical symptoms of this disease is the multiplicity of misshapen tumors and the complexity of signs and symptoms. Commonly, there are multiple polyps in the large intestine, small intestine, stomach, esophagus and other digestive tracts; multiple wart-like pimples on the neck, face and other skin; fibroadenomas, breast cancer and other mammary gland lesions; and multiple thyroid nodules, thyroid adenomas, thyroid cancer and other thyroid gland lesions. In addition, lesions of varying nature and degree can occur in all systems of the body. 3. Treatment. Treatment should be tailored to the different symptoms. Such as the use of enteroscopy, take ligation or polyp removal, a few patients may have to remove part of the colon or even the whole colon. 4. Dietary regulation. Eat more fiber-containing fruits and vegetables, eat less spicy and stimulating food, and prohibit smoking and alcohol. 5. Normal care. Maintain a positive and optimistic attitude, live a regular life, pay attention to rest, do not overwork.