Bone metastasis of breast cancer, inability to walk, is a manifestation of advanced stage of breast cancer, which is related to the destruction of bone quality. Breast cancer is a malignant tumor in breast surgery. In the early stage of the disease, the lesion needs to be removed through surgery in time to control the disease in time, so as to avoid recurrence of breast cancer or metastasis of cancer cells. Once the cancer cells show bone metastasis, it means that the breast cancer has entered the advanced stage, and the cancer cells invade the bones, which will lead to the destruction of the bone quality as well as the local nerves. This will lead to symptoms such as weakness of legs, pain in bones, loss of consciousness in legs and inability to walk. This situation is more serious and requires timely radiotherapy and chemotherapy to alleviate the symptoms, improve the patient’s quality of life and prolong the survival time as much as possible. It is recommended that patients with breast cancer should consult the doctor in time and actively cooperate with the doctor for appropriate treatment.