The probability of an enlarged lymph node being a lymphoma is very low, and most of the time it is a proliferation of lymphoid follicles due to inflammation. Enlarged lymph nodes are commonly associated with lymphoma, lymphadenitis, mostly the latter, and a lymph node biopsy is required for a definitive diagnosis. Generalized lymph node enlargement, accompanied by night sweats, weight loss, and persistent fever often suggests a high likelihood of lymphoma. Localized lymph node enlargement, such as submandibular lymph node enlargement, accompanied by pharyngeal pain, etc., is often indicative of lymphadenitis. Clinical clear diagnosis of lymph node biopsy, pathologic examination is the gold standard of diagnosis. If the diagnosis is lymphoma, it is necessary to further carry out the diagnosis of lymphoma typing, different types of lymphoma, different treatment programs, and the prognosis is also different. Enlarged lymph nodes require medical attention to clarify the nature.