These symptoms of Parkinson’s disease make patients suffer from slow movements, difficulty in dressing and eating, slurred speech, and dreamy sleep ……. These symptoms are obvious in the early stage of taking levodopa drugs, but the effect of the drugs is shortened after a long period of time, and the “end-of-dose phenomenon” appears. Patients with PD should strictly follow the doctor’s instructions and come to the hospital for regular follow-ups to adjust their medication. Patients who intend to undergo surgery should also be admitted to the hospital as early as possible for medical evaluation to avoid missing the best time for surgery. This is a typical case, let’s take a look. Name: Lxh Gender: male Age: 67 years old Condition at admission: patient complained of “right-sided limb tremor for 10 years, aggravated with left lower limb tremor for 5 years.” The patient’s right limb tremor appeared 10 years ago without any obvious cause, which was obvious at rest, aggravated by emotional excitement, reduced by casual movement, and disappeared during sleep, as well as feeling stiffness of the limbs, clumsiness of fine activities of the right limbs, walking and dragging of the right lower limbs, and gradual development of slow movements, manifested by slow rising, difficulty in starting to move, and slow movements of dressing, buttoning, eating, etc. He was referred to the local hospital and diagnosed as He was diagnosed with “Parkinson’s disease” and was given “Medroba and Antan” orally, after which his tremor and tonic symptoms partially improved. In the past year, the patient felt that he had slurred speech, tremor of the left lower limb, easy sweating, dreamy sleep and sleepy talk, the effect of the medication starts in two hours and decreases in four hours, no limb pain or numbness during the course of the disease, no muscle atrophy and no cognitive decline. In order to seek further treatment, he came to our outpatient clinic today and was admitted to our department as “Parkinson’s disease”. After the disease, he was mentally fine, with poor night rest, dreamy sleep, dry stool, about once every 3-4 days, and normal urine. Preliminary diagnosis: Parkinson’s disease Treatment: After admission, the patient’s diagnosis of Parkinson’s disease was clear, there were indications for surgery and no contraindications to surgery. Condition at discharge: The patient was in generally good condition, with clear consciousness, good mental status, stable vital signs, normal body temperature, acceptable food and stool, good general activity, and incisional healing class A/I. The physician instructed that he could be discharged from the hospital. Discharge instructions: pay attention to rest, strengthen nutrition. Follow up on indisposition. When the long-term efficacy of Parkinson’s disease medication is significantly diminished, along with symptom fluctuations: end-of-dose phenomenon, “on-off” phenomenon, and dyskinesia (movement disorder), DBS surgery may be considered. It is important to emphasize that postoperative patients still need to apply medication, but the dose can be reduced by 1/3-1/2.