Unlike regular needles, indwelling needles are softer and can be retained in the blood vessels for a longer period of time. However, there are disadvantages to indwelling needles. First, indwelling needles are more expensive, costing about$30-50 per needle, with prices varying from manufacturer to manufacturer. Second, the indwelling needle and the retention in the indwelling needle may cause pain to the area where the needle is placed, the patient is not comfortable bathing, and the pain is more pronounced when moving. Once again, the indwelling needle may be retained in the blood vessel for a long time and may cause extravasation of drugs as well as extravasation of blood. Finally, retention needles may cause secondary bacterial infections because bacteria may enter the bloodstream from the retention needle, which may cause bacteremia or sepsis.