This is a concern that many patients have. In fact, although there are differences in the intensity of action and dose of various diuretics, the adverse effects are not significantly different. Electrolyte disorders: low potassium, low chloride, low sodium, low magnesium, and even low potassium chlorosis. Among them, the most obvious is low potassium. Low potency diuretics have no secondary adverse effects. 2. hyperuricemia: a few patients can induce acute gouty arthritis attack, with gout is prohibited thiazide diuretics, if the renal insufficiency is also not suitable for thiazide diuretics. 3. abnormal blood sugar: long-term application of large amounts of blood sugar can increase, reduce glucose tolerance and increase insulin resistance in hypertensive patients. Therefore, patients with mild diabetes combined with hypertension should be used in small doses or in combination with other antihypertensive drugs. 4. Lipid metabolism disorders: thiazide diuretics can lead to an increase in total cholesterol, LDL and triglycerides. It is advisable to combine with angiotensin-converting enzyme inhibitors. The above-mentioned adverse reactions are related to the amount of medication, within a certain range, diuretic antihypertensive drugs with increasing doses of antihypertensive effect increases and the increase in adverse reactions is not obvious. However, after a certain dose, the increase in dose does not increase the antihypertensive effect, but the adverse effects increase significantly, causing some harm to patients. After recognizing this feature, people use small doses of diuretics, especially in combination with other drugs, to bring benefits to human health.