Three plus signs of urine protein often suggest that the following problems may exist: 1. Pathological problems, the most common is a problem with the kidneys, such as patients who have nephritis or nephrotic syndrome conditions, which can lead to a large amount of protein urine in the urine. At this time, kidney pathology examination should be done to clarify which specific type of pathology is involved, and according to different pathological types, different measures should be taken to treat it. Often, hormones are used. The patient’s urine protein may disappear on its own when the infection is effectively controlled. 3. plus, such as strenuous exercise, may occur. However, a small amount of proteinuria can occur with strenuous exercise, and a large amount of proteinuria is relatively uncommon.