How many years a 65-year-old man can live with myeloma cannot be determined, the median survival period is mostly related to the degree of the disease and treatment methods and other factors, ranging from a few months to about 10 years. Myeloma is a kind of malignant tumor originated from bone marrow plasma cells, which can be divided into smoldering myeloma, isolated plasma cell tumor, plasma cell leukemia and multiple myeloma. Different types of myeloma have different degrees of disease and treatment methods, and the median survival period is also different. 1. multiple myeloma: with the continuous progress of medical technology, the median survival period of multiple myeloma has been extended, up to about 5 years. 2. smoldering myeloma: the median survival is about 9 years for low-risk patients, 5 years for intermediate-risk patients, and 2 years for high-risk patients. 3. Isolated plasmacytoma: most can progress to multiple myeloma, median survival is about 10 years. 4. plasma cell leukemia: generally poor prognosis, the median survival of primary plasma cell leukemia is mostly about 0.5 to 1 year, and the median survival of secondary plasma cell leukemia may be even shorter, about 2 to 7 months. Myeloma in 65-year-olds is associated with relatively more transplant-related complications due to older age, poorer general condition, and it is recommended to strictly follow medical advice, standardize treatment, and review regularly for a longer survival time.