The eyes may not open because of the following diseases: 1. myasthenia gravis, when the upper eyelid muscle is involved, the upper eyelid droops, the eyes open with difficulty and cannot open, the symptoms are often light in the morning and heavy in the evening, and can partially improve after rest, the neostigmine test can help confirm whether this is the disease. 2. myotonic dystrophy, generally related to genetics, can start in childhood, and as age increases The disease is a genetic condition that begins in childhood and progresses chronically with age, becoming progressively worse and manifesting itself as weakness of the eyelid muscles, often combined with muscle weakness, atrophy and pseudohypertrophy of the face and other parts of the body. 3. ophthalmic myasthenia gravis, most often seen in middle-aged and older women, often involves involuntary blinking, and in the later stages of the disease, both eyes are affected at the same time, making it difficult to open the eyes and unable to see, sometimes requiring the use of fingers to lift the eyelids in order to see something outside. 4. Eye inflammation, conjunctivitis, increased secretions, adhesion of the eyelashes, resulting in inability to open the eyes, keratitis, which can lead to photophobia and difficulty in opening the eyes, wheals of the eyelids, abscesses or orbital cellulitis causing eyelid edema. 5. Visual fatigue or lack of sleep, which can lead to sore eyes, heavy eyelids, difficulty in opening the eyes, accompanied by dry eyes, photophobia, etc. 6. Conjunctival or corneal foreign body, corneal epithelial damage, causing corneal irritation symptoms, resulting in difficulty in eye opening, accompanied by lacrimation.