Chemotherapy is a very important means for the treatment of cholangiocarcinoma, and almost all cholangiocarcinoma patients need to use this method for tumor treatment. However, chemotherapy has some toxic side effects, so patients need to take good care of themselves after using chemotherapy. Then how to take care of bile duct cancer after chemotherapy? Many anti-tumor drugs, such as nitrogen mustard, antibiotic, vincristine, etc., have strong local stimulation, and if they are injected into subcutaneous due to careless operation, they can cause tissue necrosis and even prolonged healing, and improper injection can cause phlebitis. In the process of using, patients should be given good explanations to eliminate nervousness and introduce the nature of drugs, toxicity and side effects, so as to make the patients have a clear idea in advance, and to prevent the patients from causing adverse consequences due to their strong tolerance or barely enduring pain and not reporting to the health care personnel. 2.Gastrointestinal reactions may appear after chemotherapy for bile duct cancer Most of the antitumor drugs have damaging effect on mucous membrane of digestive tract, which often manifests as gastrointestinal reactions such as loss of appetite, nausea, vomiting, diarrhea and so on. For example, fluorouracil and methotrexate can cause frequent diarrhea and even blood in stool. Most of the patients have heavy reaction for the first time, and then gradually reduce. In the process of applying anticancer drugs, patients should be concerned about their eating situation and be given light diet with easy digestion and less fat. For patients with heavy drug reaction, it is better to arrange the drug application before bedtime or after meal, so as not to affect eating. Those with serious vomiting should eat less and more meals, and replenish fluids when necessary.